Biocomposites announces U.S. launch of new STIMULAN® Rapid Cure 3cc product

Targeting smaller voids in foot and ankle, orthopaedic reconstruction and trauma


Uniquely engineered for the precision and control you demand every time

Bullet Mat and Introducer

Streamlined, flexible design that simplifies delivery of STIMULAN into hard-to-reach defects.

Perfect partner for cases with an infected site

STIMULAN is a truly absorbable calcium sulfate precision engineered to complement your dead space management – may help to improve surgical outcomes and lower overall costs of care.

  • Cleared for placement directly at site of infection in bone voids and defects¹

Consistency is hard earned and uniquely achieved

STIMULAN is uniquely engineered through our DRy26™ recrystallization method.2 Each and every synthesis undergoes a 26 step process that starts with pharmaceutical grade precursors and takes over 6 weeks to reach maturity.

Properties that drive performance

The unique crystal configuration and construction of STIMULAN brings its own set of qualities to fully support your infected cases.

  • Controlled purity
  • No hydroxyapatite, insoluble impurities or PMMA debris
  • Hydrophilic

See the STIMULAN difference in your cases

  • Truly absorbable1, 3-9
  • Optimal absorption profile1, 3-9
  • Reliable setting time9
  • Does not cause third body damage10-12
  • Does not prevent use in articulating surfaces10-12
  • Does not act as a nidus for infection1, 3-8
Truly absorbable and totally synthetic calcium sulfate – absorbs at an optimal rate

Leaves no nidus for infection.

1 month
11 weeks
6 months
Hydrophilic for fast, easy mixing

No soaking required

STIMULAN - mixes with liquid
Competitor calcium sulfate - repels liquid
No third body damage to articulating surfaces

Less scratching than competitor calcium sulfate

STIMULAN does not damage total knee replacements when trapped between the articulating surfaces of the implant

Microscope images (x6.5) of a cobalt chrome plate following damage simulation(360,000 cycles) with third body particles trapped between it and an articulating UHMWPE pin

Competitor calcium sulfate

Unrivaled evidence and expertise bring confidence

With our industry-leading knowledge, dedication and experience, you can be sure that the high level of consistency you demand in your cases will be met.

Case-by-case flexibility

Every part of STIMULAN has been designed to provide simplicity, intra-operative flexibility and optimum results. A variety of formats are available, all convenient and fast to set

No challenge too large or small

Introducing the new STIMULAN Rapid Cure 3cc pack size with combination bead and bullet mat for smaller void volumes.

  • Versatile application
  • Full range of bead and bullet sizes
  • Reduce waste
STIMULAN® products
STIMULAN® Bullet Mat and Introducer

Innovative design that simplifies delivery into hard-to-reach defects.

  • Bullets have a groove down one side to reduce the risk of pressurizing the defect site
  • Bullets can be prepared in two diameters – 7mm and 9mm
STIMULAN® Rapid Cure

Rapid setting paste with individual bead kit.

  • Beads can be prepared in three sizes;
    3, 4.8 and 6mm
  • Available in 3cc, 5cc, 10cc and 20cc packs (bead volume 7cc, 12cc, 25cc and 50cc)
  • Rapid setting in approx. 4 minutes

Standard setting, fully injectable paste with individual bead kit.

  • Beads can be prepared in three sizes;
    3, 4.8 and 6mm
  • Available in 5cc and 10cc packs (bead volume 10cc and 20cc)
  • Standard setting in approx. 8 minutes
STIMULAN - power to transform
STIMULAN Bullet Mat and Introducer technique guide
How to prepare STIMULAN Rapid Cure
Hear what surgeons have to say about STIMULAN
Dr Hohman case study - tibial osteomyelitis
Dr Wassef case study - infected hip revision
Dr Webb case study - bilateral high energy femoral fractures
Hear what surgeons have to say about STIMULAN

Listed below are 4 of the most relevant articles for this product but there is much more unrivalled evidence to explore on our Library page.

Explore Library

References and regulatory statements

1. Biocomposites Ltd, STIMULAN Instructions for Use. 2.  Cooper, J.J., Method of producing surgical grade calcium sulphate; Patent. 1999. 3. Somasundaram, K., et al., Proximal humeral fractures: the role of calcium sulphate augmentation and extended deltoid splitting approach in internal fixation using locking plates. Injury, 2013. 44(4): p. 481-7. 4. Lei, D., et al., Treatment of Distal Radius Bone Defects with Injectable Calcium Sulphate Cement., in Bone Grafting, A. Zorzi, Editor. 2012, InTech. p. 125-134. 5. Lei, D., L. Jing, and S. Yang-yong, Calcium sulfate versus calcium phosphate in treating traumatic fractures. JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH., 2008. 12. 6. Lei, D., Z. Ma, and X. Jing, Treatment of bone defect with injectable calcium sulfate powder in distal fractures of radius. Chinese Journal of Bone Tumor and Bone Disease, 2007. 7. Aiken, S.S., J.J. Cooper, and S. Zhou, Osseointegration of a calcium sulphate bone substitute in a large animal model, in The 5th International Congress of Chinese Orthopaedic Association. 2010: Chengdu, China. 8. Lazarou, S.A., G.B. Contodimos, and I.D. Gkegkes, Correction of alveolar cleft with calcium-based bone substitutes. J Craniofac Surg, 2011. 22(3): p. 854-7. 9. Biocomposites, Data on file. 10. Cowie, R.M., et al., Influence of third-body particles originating from bone void fillers on the wear of ultra-high-molecular-weight polyethylene. Proc Inst Mech Eng H, 2016. 230(8): p. 775-83. 11. Cowie, R.M., et al., The Influence of Third Body Damage by a Calcium Sulfate Bone Void Filler on the Wear of Total Knee Replacements., in Orthopaedic Research Society Annual Meeting. 2016: Orlando, FL. p. 103. 12. Lewicki, K., et al., The Effect of Absorbable Calcium Sulfate on Wear Rates in Ultra-high-Molecular-weight Polyethylene: Potential Implications for Its Use in Treating Arthroplasty Infections. J Am Acad Orthop Surg, 2017.

For indications, contraindications, warnings and precautions see Instructions for Use. Concurrent use of locally administered antibiotics may affect setting time.
This brochure may include the use of STIMULAN or techniques that go beyond the current clearance/approval granted by the relevant regulatory authority. Please contact your local representative for further information.
©2024, Biocomposites, STIMULAN, Bringing Calcium to Life, Power to Transform and DRy26 are trademarks/registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorized copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd.

Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710, EP 3058899 B1, US 10390954, US 10,588,748, CN ZL201610089710.5
Patents pending: GB1502655.2, GB1704688.9, EP 18275044.8, US 15/933936, CN 108619579A