Combination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded PMMA in the treatment of chronic osteomyelitis

Luo, S., et al. BMC Musculoskeletal Disorders, 2016. 17(1): p. 502.

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This is a retrospective study of 51 patients suffering from post-traumatic or postoperative osteomyelitis of the lower extremities. The aim of the study was to compare the outcomes of patients treated with antibiotic loaded PMMA spacers (Control group) and patients treated with a combination therapy of antibiotic loaded PMMA spacers and antibiotic loaded calcium sulphate (STIMULAN) (Study group). Overall infection eradication rates after repeat operation were 96.15% (25/26) in the Study group and 72% (18/25) in the Control group. There were no persistent infections in the study group. Re-operation rates were higher in the control group (9) compared to the study group (2). The abstract can be read, and the full paper can be obtained here.

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