Development of a Novel Model for the Assessment of Dead-Space Management in Soft Tissue

Oliver, R.A., et al. PLoS ONE, 2015. 10(8): p. e0136514.

Products: STIMULAN®

In this animal study STIMULAN was assessed for its effectiveness at managing dead space created in muscle tissue that can be a result of extensive debridement due to surgical treatment of infection. STIMULAN was used as a carrier material for vancomycin and tobramycin. STIMULAN was implanted into the dead space in muscle tissue where host tissue response and healing were monitored. The model demonstrates resolution of dead space, complete absorption of STIMULAN within 21 days, biocompatibility within soft tissue and at 72 hours after implantation antibiotic serum levels were non-detectable. The abstract and full paper can be read here.

Library

Listed below are 4 of the most relevant articles for this piece but there is much more to explore on our Library page.

Explore Library

SYNICEM™ spacers

Two-stage total infected knee arthroplasty treatment with articulating cement spacer

Elution Kinetics from Antibiotic-Loaded Calcium Sulfate Beads, Antibiotic-Loaded Polymethacrylate Spacers, and a Powdered Antibiotic Bolus for Surgical Site Infections in a Novel In Vitro Draining Knee Model

Efficacy of topical vancomycin and gentamicin loaded calcium sulfate beads or systemic antibiotics in eradicating polymicrobial biofilms isolated from diabetic foot infections within an in vitro wound model

Assessing the bioactive profile of anti-fungal loaded calcium sulfate against fungal biofilms

Transform Infected Femur

View case study >

Intramedullary reaming and irrigation and antibiotic-loaded calcium sulfate implantation for the treatment of infection after intramedullary nailing: a retrospective study of 19 cases

Hong-An Zhang, Chun-Hao Zhou, Xiang-Qing Meng, Jia Fang & Cheng-He Qin. BMC Musculoskeletal Disorders volume 21, Article number: 710 (2020).

STIMULAN®, genex®

Comparative osteoconductivity of bone void fillers with antibiotics in a critical size bone defect model

Rema A. Oliver, Vedran Lovric, Chris Christou, William R. Walsh. Journal of Materials Science: Materials in Medicine (2020) 31:80.

A novel treatment approach to infected nonunion of long bones without systemic antibiotics

Masrouha, K.Z., M.E. Raad, and S.S. Saghieh. Strategies Trauma Limb Reconstr, 2018.

Transform osteomyelitis in diabetic foot

View case study >

Calcium sulphate as a drug delivery system in a deep diabetic foot infection

Morley, R., F. Lopez, and F. Webb. Foot (Edinb), 2016. 27: p. 36-40.

Transform infected revision arthroplasty

View case study >

Managing lower-extremity osteomyelitis locally with surgical debridement and synthetic calcium sulfate antibiotic tablets

Gauland, C. Adv Skin Wound Care, 2011. 24(11): p. 515-23.

Femoral neck stress fracture

View case study >

Use of Highly Purified Synthetic Calcium Sulfate Impregnated with Antibiotics for the Management of Diabetic Foot Ulcers Complicated by Osteomyelitis

Jogia, R.M., et al. Diabetes Care, 2015. 38(5): p. e79-e80.

Dissolvable Antibiotic Beads in Treatment of Periprosthetic Joint Infection and Revision Arthroplasty. The Use of Synthetic Pure Calcium Sulfate (Stimulan®)Impregnated with Vancomycin & Tobramycin

McPherson, E.J., M.V. Dipane, and S.M. Sherif,. Reconstructive Review, 2013. 3(1): p. 32-43.

Transform osteomyelitis in diabetic foot

View case study >

Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model

Oliver, R. A., et al. (2019). J Biomater Appl: 885328219838382.

Transform infected trauma

View case study >

Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin

Maale, G. E., et al. (2020). European Journal of Drug Metabolism and Pharmacokinetics

Is Hypercalcemia a Frequent Complication following Local Use of Calcium Sulfate with Antibiotics for the Treatment of Extremity Posttraumatic Osteomyelitis? A Preliminary Study

Jiang, N., et al. BioMed Research International, 2019.

Transform infected revision arthroplasty

View case study >

Management of Osteomyelitis-Induced Massive Tibial Bone Defect by Monolateral External Fixator Combined with Antibiotics-Impregnated Calcium Sulphate: A Retrospective Study

Qin, C., et al., BioMed Research International, 2018. 2018: p. 8.

Transform talonavicular septic arthritis

View case study >

Infected revision THA

View case study >

Transform chronic draining sinus with serratia in left ankle

View case study >

Combination therapy with vancomycin-loaded calcium sulfate and vancomycin-loaded PMMA in the treatment of chronic osteomyelitis

Luo, S., et al. BMC Musculoskeletal Disorders, 2016. 17(1): p. 502.

Determination of the elution kinetics of antibiotic-loaded calcium sulfate beads and powdered antibiotic bolus for surgical site infections

Dusane, D., et al. (2020). Orthopaedic Research Society Annual Meeting. Phoenix, AZ.

Bilateral femoral fractures

View case study >

STIMULAN®, genex®

Infected Knee Joint

View case study >

An unusual complication following Charcot neuroarthropathy

Morley, R. and F. Webb. The Diabetic Foot Journal, 2018. 21(2): p. 107-114.

Transform infected humerus

View case study >

Transform osteomyelitis caused by Group B Streptococcus and MRSA

View case study >

Use of STIMULAN absorbable calcium sulphate beads in revision lower limb arthroplasty

Kallala, R., et al. Bone & Joint Research, 2018. 7(10): p. 570-579.

Transform osteomyelitis caused by MRSA

View case study >

Local bio-absorbable antibiotic delivery in calcium sulfate beads in hip and knee arthroplasty

Lum, Z.C. and G.C. Pereira, Journal of Orthopaedics, 2018. 15(2): p. 676-678.

Careful interpretation of the wound status is needed with use of antibiotic impregnated biodegradable synthetic pure calcium sulfate beads: Series of 39 cases

Menon, A., et al. J Bone Jt Infect, 2018. 3(2): p. 87-93.

Static antibiotic spacers augmented by calcium sulphate impregnated beads in revision TKA: Surgical technique and review of literature

Risitano, S., et al. Journal of Orthopaedics, 2018. 15(2): p. 313-318.